One-Pot Peptide Ligation – Oxidative Cyclization Protocol for the Preparation of Short/Medium Size Disulfide Cyclopeptides

Spengler, Jan; Blanco Canosa, Juan B.; Forni, Luciano; Albericio, Fernando

dc.contributor.author	Spengler, Jan
dc.contributor.author	Blanco Canosa, Juan B.
dc.contributor.author	Forni, Luciano
dc.contributor.author	Albericio, Fernando
dc.date.accessioned	2019-06-11T12:51:48Z
dc.date.available	2019-06-11T12:51:48Z
dc.date.issued	2018
dc.identifier.citation	Spengler, J., Blanco Canosa, J. B., Forni, L., & Albericio, F. (2018). One-Pot Peptide Ligation–Oxidative Cyclization Protocol for the Preparation of Short-/Medium-Size Disulfide Cyclopeptides. Organic letters, 20(14), 4306-4309. doi:10.1021/acs.orglett.8b01741.	es
dc.identifier.other	https://doi.org/10.1021/acs.orglett.8b01741
dc.identifier.uri	http://repositorio.ikiam.edu.ec/jspui/handle/RD_IKIAM/213
dc.identifier.uri	https://doi.org/10.1021/acs.orglett.8b01741
dc.description.abstract	Native chemical ligation (NCL) employing the N-methylbenzimidazolinone (MeNbz) linker readily provided the linear precursor of a 16-mer peptide that is diﬃcult to obtain by stepwise solid-phase peptide synthesis. NCL and the workup conditions were improved toward a protocol that allows for quantitative removal of the 4-hydroxymercapto- phenol additive and subsequent formation of the disulﬁde bridge in the NCL cocktail by oxidation in air, tolerated by the presence of tris(hydroxypropyl)phosphine.	es
dc.language.iso	en	es
dc.publisher	American Chemical Society	es
dc.relation.ispartofseries	PRODUCCIÓN CIENTÍFICA-ARTÍCULOS;A-IKIAM-000150
dc.rights	Atribución-NoComercial-SinDerivadas 3.0 Estados Unidos de América	*
dc.rights	openAccess	es_ES
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0/us/	*
dc.subject	Ligation–Oxidativ	es
dc.subject	Cyclopeptides	es
dc.subject	Disulfide	es
dc.title	One-Pot Peptide Ligation – Oxidative Cyclization Protocol for the Preparation of Short/Medium Size Disulfide Cyclopeptides	es
dc.type	Article	es