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dc.contributor.author | Spengler, Jan | |
dc.contributor.author | Barker, Michael | |
dc.contributor.author | Schelhorn, Constanze | |
dc.contributor.author | García, Jesús | |
dc.contributor.author | Macias, Maria J. | |
dc.contributor.author | Albericio, Fernando | |
dc.date.accessioned | 2019-06-12T20:17:45Z | |
dc.date.available | 2019-06-12T20:17:45Z | |
dc.date.issued | 2017 | |
dc.identifier.citation | Spengler, J., Barker, M., Schelhorn, C., García, J., Macias, M. J., & Albericio, F. (2017). The synthesis of an EDTA-like chelating peptidomimetic building block suitable for solid-phase peptide synthesis. Chemical Communications, 53(17), 2634–2636. doi:10.1039/c6cc10203d | es |
dc.identifier.other | https://doi.org/10.1039/C6CC10203D | |
dc.identifier.uri | http://repositorio.ikiam.edu.ec/jspui/handle/RD_IKIAM/246 | |
dc.identifier.uri | https://doi.org/10.1039/C6CC10203D | |
dc.description.abstract | A novo trifunctional EDTA-like peptidomimetic amino acid is described. This unique building block, which is prepared in a straightforward manner from commercialized starting materials, contains three moieties: a hexadentate chelating unit similar to that present in EDTA, and amino and carboxylic groups, which facilitate its introduction into the backbone of peptides using conventional SPPS. As a proof of concept, this building block is introduced into a cyclic peptide inspired from the family of Gratisin analogues. The designed peptide contains the amino acid analogue in one of the turns, and chelates Ca2+ with nanomolar affinity at physiological pH. | es |
dc.language.iso | en | es |
dc.publisher | Royal Society of Chemistry | es |
dc.relation.ispartofseries | PRODUCCIÓN CIENTÍFICA-PARTE LIBROS;AL-IKIAM-000004 | |
dc.rights | Atribución-NoComercial-SinDerivadas 3.0 Estados Unidos de América | * |
dc.rights | openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/us/ | * |
dc.subject | Peptide | es |
dc.subject | EDTA | es |
dc.title | The synthesis of an EDTA-like chelating peptidomimetic building block suitable for solid-phase peptide synthesis | es |
dc.type | Article | es |
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