Por favor, use este identificador para citar o enlazar este ítem: http://repositorio.ikiam.edu.ec/jspui/handle/RD_IKIAM/61
Registro completo de metadatos
Campo DC Valor Lengua/Idioma
dc.contributor.authorde Almeida, José R.-
dc.contributor.authorPalacios, Antonio L.V.-
dc.contributor.authorPalma Patiño, Ricardo Sebastián-
dc.contributor.authorMendes, Bruno-
dc.contributor.authorTeixeira, Cátia A.S.-
dc.contributor.authorGomes, Paula-
dc.contributor.authorda Silva, Saulo L.-
dc.identifier.citationAlmeida, J. R., Palacios, A. L. V., Patiño, R. S. P., Mendes, B., Teixeira, C. A. S., Gomes, P., & da Silva, S. L. (2019). Harnessing snake venom phospholipases A 2 to novel approaches for overcoming antibiotic resistance. Drug Development Research, 80, 68–85. doi:10.1002/ddr.21456es
dc.description.abstractThe emergence of antibiotic resistance drives an essential race against time to reveal new molecular structures capable of addressing this alarming global health problem. Snake venoms are natural catalogs of multifunctional toxins and privileged frameworks, which serve as potential templates for the inspiration of novel treatment strategies for combating antibiotic resistant bacteria. Phospholipases A2 (PLA2 s) are one of the main classes of antibacterial biomolecules, with recognized therapeutic value, found in these valuable secretions. Recently, a number of biomimetic oligopeptides based on small fragments of primary structure from PLA2 toxins has emerged as a meaningful opportunity to overcome multidrug-resistant clinical isolates. Thus, this review will highlight the biochemical and structural properties of antibacterial PLA2 s and peptides thereof, as well as their possible molecular mechanisms of action and key roles in development of effective therapeutic strategies. Chemical strategies possibly useful to convert antibacterial peptides from PLA2 s to efficient drugs will be equally addressed.es
dc.description.sponsorshipJohn Wiley & Sons Inc.es
dc.publisherInternational Journal of Drug Development and Researches
dc.relation.ispartofseriesPRODUCCION CIENTÍFICA-ARTÍCULOS;A-IKIAM-000004-
dc.subjectAntibacterial peptideses
dc.subjectAntibiotic -resistant bacteriaes
dc.subjectPhospholipase A2es
dc.subjectSnake venomes
dc.titleHarnessing snake venom phospholipases A2 to novel approaches for overcoming antibiotic resistancees
Aparece en las colecciones: ARTÍCULOS CIENTÍFICOS

Ficheros en este ítem:
Fichero Descripción Tamaño Formato  
A-IKIAM-000004.pdfHarnessing snake venom phospholipases A2 to novel approaches for overcoming antibiotic resistance2,67 MBAdobe PDFVista previa

Los ítems de DSpace están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.