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Título : Snake Venom, A Natural Library of New Potential Therapeutic Molecules: Challenges and Current Perspectives
Autor : Simoes Silva, Rodrigo
Alfonso, Jorge
Gomez, Ana F.
Holanda, Rudson J.
Sobrinho, Juliana C.
Zaqueo, Kayena D.
Moreira Dill, Leandro S.
Kayano, Anderson M.
Grabner, Fernando P.
da Silva, Saulo L.
de Almeida, José R.
Stabeli, Rodrigo G.
Zuliani, Juliana P.
Soares, Andreimar M.
Palabras clave : Snake venoms
Protein purification
Biotechnological applications
New therapeutics.
Fecha de publicación : 2018
Editorial : Bentham Science
Citación : Simoes-Silva, R., Alfonso, J., Gomez, A., Holanda, R. J., Sobrinho, J. C., Zaqueo, K. D., … Soares, A. M. (2018). Snake Venom, A Natural Library of New Potential Therapeutic Molecules: Challenges and Current Perspectives. Current Pharmaceutical Biotechnology, 19(4), 308–335. doi:10.2174/1389201019666180620111025
Resumen : Background: Research involving snake venom has gradually surpassed the simple discovery of new molecules using purification and structural characterization processes, and extended to the identification of their molecular targets and the evaluation of their therapeutic potential. Nevertheless, this only became possible due to constant progress in experimental biology and protein purification approaches. Objective: This review aims to discuss the main components of snake venoms that have been investigated for biotechnological purposes, and to discover how these promising biomolecules were obtained with the satisfactory degree of purity that have enabled such studies. Advances in purification technologies of various snake venom molecules have allowed for important discoveries of proteins and peptides with different biomedical and biotechnological applications. Result and Conclusion: It is believed that significant experimental and computational advances will arise in similar proportions in the coming years that will allow researchers to map the molecular regions responsible for their pharmacological actions, their respective mechanisms of action and their cell targets.
URI : http://repositorio.ikiam.edu.ec/jspui/handle/RD_IKIAM/240
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