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dc.contributor.authorSpengler, Jan-
dc.contributor.authorBlanco Canosa, Juan B.-
dc.contributor.authorForni, Luciano-
dc.contributor.authorAlbericio, Fernando-
dc.date.accessioned2019-06-11T12:51:48Z-
dc.date.available2019-06-11T12:51:48Z-
dc.date.issued2018-
dc.identifier.citationSpengler, J., Blanco Canosa, J. B., Forni, L., & Albericio, F. (2018). One-Pot Peptide Ligation–Oxidative Cyclization Protocol for the Preparation of Short-/Medium-Size Disulfide Cyclopeptides. Organic letters, 20(14), 4306-4309. doi:10.1021/acs.orglett.8b01741.es
dc.identifier.otherhttps://doi.org/10.1021/acs.orglett.8b01741-
dc.identifier.urihttp://repositorio.ikiam.edu.ec/jspui/handle/RD_IKIAM/213-
dc.identifier.urihttps://doi.org/10.1021/acs.orglett.8b01741-
dc.description.abstractNative chemical ligation (NCL) employing the N-methylbenzimidazolinone (MeNbz) linker readily provided the linear precursor of a 16-mer peptide that is difficult to obtain by stepwise solid-phase peptide synthesis. NCL and the workup conditions were improved toward a protocol that allows for quantitative removal of the 4-hydroxymercapto- phenol additive and subsequent formation of the disulfide bridge in the NCL cocktail by oxidation in air, tolerated by the presence of tris(hydroxypropyl)phosphine.es
dc.language.isoenes
dc.publisherAmerican Chemical Societyes
dc.relation.ispartofseriesPRODUCCIÓN CIENTÍFICA-ARTÍCULOS;A-IKIAM-000150-
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 Estados Unidos de América*
dc.rightsopenAccesses_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.subjectLigation–Oxidatives
dc.subjectCyclopeptideses
dc.subjectDisulfidees
dc.titleOne-Pot Peptide Ligation – Oxidative Cyclization Protocol for the Preparation of Short/Medium Size Disulfide Cyclopeptideses
dc.typeArticlees
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