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Título : In vitro effects of Crotalus atrox snake venom on chick and mouse neuromuscular preparations
Autor : Schezaro Ramos, Raphael
da Silva, Saulo L.
Pereira, Beatriz B.
Santa Fé, Ananda T.
Bruno, Mendes
Carregari, Victor C.
Salazar Mogollón, Noroska Gabriela
de Almeida, José R.
Hyslop, Stephen
Palabras clave : Crotalus atrox
Neuromuscular blockade
Snake venom
Fecha de publicación : 2018
Editorial : Elsevier
Citación : Schezaro-Ramos, R., Da Silva, S. L., Pereira, B. B., Santa Fé Miguel, A. T., Mendes, B., Mogollón, N. G. S., … Almeida, J. R. (2018). In vitro effects of Crotalus atrox snake venom on chick and mouse neuromuscular preparations. Comparative Biochemistry and Physiology Part - C: Toxicology and Pharmacology, 209, 37–45. doi:10.1016/j.cbpc.2018.03.008
Resumen : The neuromuscular effect of venoms is not a major clinical manifestation shared between rattlesnakes native to the Americas, which showed two different venom phenotypes. Taking into account this dichotomy, nerve muscle preparations from mice and chicks were used to investigate the ability of Crotalus atrox venom to induce in vitro neurotoxicity and myotoxicity. Unlike crotalic venoms of South America, low concentrations of C. atrox venom did not result in significant effects on mouse neuromuscular preparations. The venom was more active on avian nerve-muscle, showing reduction of twitch heights after 120 min of incubation with 10, 30 and 100 μg/mL of venom with diminished responses to agonists and KCl. Histological analysis highlighted that C. atrox was myotoxic in both species of experimental animals; as evidenced by degenerative events, including edematous cells, delta lesions, hypercontracted fibers and muscle necrosis, which can lead to neurotoxic action. These results provide key insights into the myotoxicity and low neurotoxicity of C. atrox in two animal models, corroborating with previous genomic and proteomic findings and would be useful for a deeper understanding of venom evolution in snakes belonging to the genus Crotalus.
URI : http://repositorio.ikiam.edu.ec/jspui/handle/RD_IKIAM/212
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