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dc.contributor.authorde Almeida, José R.-
dc.contributor.authorMonteiro Resende, Letícia-
dc.contributor.authorWatanabe, Ridha K.-
dc.contributor.authorCorassola Carregari, Victor-
dc.contributor.authorHuancahuire Vega, Salomón-
dc.contributor.authorCaldeira, C. A. da S.-
dc.contributor.authorCountinho Neto, A.-
dc.contributor.authorSoares, A. M.-
dc.contributor.authorVale, Nuno-
dc.contributor.authorGomes, Paula-
dc.contributor.authorMarangoni, S.-
dc.contributor.authorCalderon, L. de A.-
dc.contributor.authorda Silva, Saulo L.-
dc.identifier.citationAlmeida, J. R., Resende, L. M., Watanabe, R. K., Carregari, V. C., Huancahuire-Vega, S., da S. Caldeira, C. A., … Da Silva, S. L. (2017). Snake Venom Peptides and Low Mass Proteins: Molecular Tools and Therapeutic Agents. Current Medicinal Chemistry, 24(30), 3254–3282. doi:10.2174/0929867323666161028155611es
dc.description.abstractSnake venoms are natural sources of biologically active molecules that are able to act selectively and specifically on different cellular targets, modulating physiological functions. Thus, these mixtures, composed mainly of proteins and peptides, provide ample and challenging opportunities and a diversified molecular architecture to design and develop tools and agents of scientific and therapeutic interest. Among these components, peptides and small proteins play diverse roles in numerous physiological processes, exerting a wide range of pharmacological activities, such as antimicrobial, antihypertensive, analgesic, antitumor, analgesic, among others. The pharmaceutical and cosmetic industries have recognized the huge potential of these privileged frameworks and believe them to be a promising alternative to contemporary drugs. A number of natural or synthetic peptides from snake venoms have already found preclinical or clinical applications for the treatment of pain, hypertension, cardiovascular diseases and aging skin. A well-known example is captopril, whose natural peptide precursor was isolated from Bothrops jararaca snake venom, which is a peptide-based drug that inhibits the angiotensin-converting enzyme, producing an anti-hypertensive effect. The present review looks at the main peptides (natriuretic peptides, bradykinin-potentiating peptides and sarafotoxins) and low mass proteins (crotamine, disintegrins and three-Finger toxins) from snake venoms, as well as synthetic peptides inspired by them, describing their biochemical, structural and physiological features, as well as their applications as research tools and therapeutic agents.es
dc.publisherBentham Sciencees
dc.relation.ispartofseriesPRODUCCIÓN CIENTÍFICA-PARTE LIBROS;CL-IKIAM-000003-
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 Estados Unidos de América*
dc.subjectBradykinin-potentiating peptidees
dc.subjectNatriuretic peptidees
dc.subjectThree-finger toxines
dc.titleSnake Venom Peptides and Low Mass Proteins: Molecular Tools and Therapeutic Agentses
dc.typeBook chapteres
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